Design: it is a single-blind randomized clinical pilot study. Patients have been assigned to the two groups (intervention group: pericervical analgesia / control group: nitrous oxide).

Setting: this study took place at the Hysteroscopy Service of the “Degli Infermi “ Hospital in Ponderano (Italy). The Hysteroscopy Service has been equipped with soft lights and background music, to allow patients to be more relaxed during the procedure.

Patients or Participants: fifty patients were enrolled in six months, 25 in the intervention group and 25 in the control group. The inclusion criteria were: nulliparous or primiparous women, age between 25 and 50 years, without positive history of previous interventions involving the cervix.

Interventions: patients assigned to the Intervention group received pericervical anesthesia before hysteroscopy. The control group received N2O via bucconasal mask. At the end of the procedure, enrolled subjects completed the Visual Analog Scale (VAS 0-10 cm) for pain assessment.

Measurements and Main Results: the outcome of this study were the difference in mean VAS scores between the two groups. The data, still preliminary, highlighted a mean VAS score value of 5.2 in the intervention group compared to a VAS score of 7.5 in the control group (only 1 patient referred for treatment in the operating room in the intervention group, 4 patients in the control group).

Conclusion: our preliminary data demonstrate how pericervical analgesia is a safe and effective method of pain control, allowing the execution of even complex surgical procedures in an office setting, fully exploiting the high performance of Miniresectoscope.This approach achieves high patient compliance and further limits access to the operating room.Given the paucity of literature data available, additional studies are required before this information should be used in clinical settings.